1-甲基-2-氧代环戊烷羧酸甲酯合成路线 （共 16 条）
反应条件
1: benzene / 11 h / Irradiation
2: 82 percent / diethyl ether / -25 °C
3: 85 percent / pyridine, CrO3 / CH2Cl2
View Scheme
参考文献
Morizur, Jean-Pierre; Tortajada, Jeanine
Tetrahedron Letters, 1982 , vol. 23, # 50 p. 5275 - 5278
反应条件
1: 75.5 percent / diethyl ether / 2 h / Heating
2: 70 percent / P4O10 / benzene / Heating
3: 1.) NBS, azobisisobutyronitrile, 2.) quinoline / 1.) CCl4, 2.) 110 deg C
View Scheme
参考文献
Klaerner, Frank-Gerrit; Adamsky, Friedhelm
Chemische Berichte, 1983 , vol. 116, # 1 p. 299 - 322
参考文献
Morizur, Jean-Pierre; Tortajada, Jeanine
Tetrahedron Letters, 1982 , vol. 23, # 50 p. 5275 - 5278
反应条件
1: benzene / 11 h / Irradiation
2: 82 percent / diethyl ether / -25 °C
View Scheme
参考文献
Morizur, Jean-Pierre; Tortajada, Jeanine
Tetrahedron Letters, 1982 , vol. 23, # 50 p. 5275 - 5278
反应条件
1.1: methanol; sodium methylate / 3 h / Reflux; Inert atmosphere
1.2: 3 h / Reflux; Inert atmosphere
2.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere
3.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 9 h / 0 - 20 °C / Inert atmosphere
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 0 °C / Inert atmosphere
5.1: potassium hydroxide / methanol; water / 8 h / 60 °C
5.2: 20 °C / pH 1
6.1: sulfuric acid / dichloromethane; water / 16 h / 0 °C
View Scheme
参考文献
Abraham, Elin; Claridge, Timothy D.W.; Davies, Stephen G.; Odell, Barbara; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Smith, Lorna J.; Storr, Helen R.; Sweet, Miles J.; Thompson, Amber L.; Thomson, James E.; Tranter, George E.; Watkin, David J.
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 69 - 100
反应条件
sodium methylate in methanol
Heating;
参考文献
Paquer,D.; Smadja,S.
Recueil des Travaux Chimiques des Pays-Bas, 1976 , vol. 95, p. 172 - 175
