(E)-N-(3-羟基丙基)-3-苯基丙-2-烯酰胺合成路线 (共 2 条)
反应条件
1: 3-phenyl-2-propenoic acid With triethylamine; methyl chloroformate in dichloromethane T=20°C; 2 h; Cooling with ice; 2: 3-amino-propan-1-ol in dichloromethane T=20°C;
参考文献
Guan, Li-Ping; Sui, Xin; Deng, Xian-Qing; Zhao, Dong-Hai; Qu, You-Le; Quan, Zhe-Shan
Medicinal Chemistry Research, 2011 , vol. 20, # 5 p. 601 - 606
反应条件
3,3',5,5'-tetra-t-butyl-1,1'-bi(2,5-cyclohexadienyl)-4,4'-dione; 1,3-dimethyltriazolium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; chemoselective reaction;
参考文献
Samanta, Ramesh C.; De Sarkar, Suman; Froehlich, Roland; Grimme, Stefan; Studer, Armido
Chemical Science, 2013 , vol. 4, # 5 p. 2177 - 2184