4-(4-甲氧基苯胺)四氢-1(2H)-吡啶羧酸叔丁酯合成路线 （共 3 条）
反应条件
sodium cyanoborohydride in methanol T=20°C; reductive amination; 48 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 21 p. 2435 - 2439
反应条件
1: 4-methoxyphenyl magnesium bromide With titanium(IV) isopropylate in tetrahydrofuran; toluene T=-40°C; 0.0833333 h; Inert atmosphere; 2: C10H19ClN2O2 in tetrahydrofuran; toluene T=-40 - 20°C; 4 h; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 36 p. 8325 - 8328
反应条件
1.1: N-chloro-succinimide / toluene / 0.33 h / Inert atmosphere 2.1: titanium(IV) isopropylate / tetrahydrofuran; toluene / 0.08 h / -40 °C / Inert atmosphere 2.2: 4 h / -40 - 20 °C / Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 36 p. 8325 - 8328
