3-(4-氟苯基)-1H-吡唑-4-甲醛合成路线 （共 5 条）
反应条件
1: With N,N-dimethyl-formamide; trichlorophosphate T=0 - 70°C; 4 h; 2: With sodium hydroxide in water T=60°C; 0.0833333 h; Cooling;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES; YUAN, Junying; YUAN, Chengye; DEGTEREV, Alexei
Patent: WO2010/75290 A1, 2010 ;
Location in patent: Page/Page column 44-45 ;
反应条件
1: With trichlorophosphate 2: With sodium hydroxide; water
参考文献
Zheng, Weihong; Degterev, Alexei; Hsu, Emily; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 4932 - 4935
反应条件
1.1: AcONa / ethanol / 0.75 h / Heating 1.2: ethanol / 1 h / Heating 2.1: 85 percent / POCl3 / 40 - 80 °C View Scheme
参考文献
Russian Journal of General Chemistry, , vol. 75, # 5 p. 782 - 789
反应条件
sodium acetate in acetic acid Knoevenagel condensation; Reflux;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES; YUAN, Junying; YUAN, Chengye; DEGTEREV, Alexei
Patent: WO2010/75290 A1, 2010 ;
Location in patent: Page/Page column 45 ;
反应条件
potassium carbonate in acetonitrile
T=20°C;
参考文献
Zheng, Weihong; Degterev, Alexei; Hsu, Emily; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 4932 - 4935
