4-甲基-3,4-二氢-2(1H)-喹啉酮合成路线 （共 13 条）
反应条件
hydrogen; 1,4-di(diphenylphosphino)-butane; 1-n-butyl-3-methylimidazolium hexafluorophosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex T=90°C; P=31028.9 Torr; 45 h;
参考文献
Ye, Fangguo; Alper, Howard
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 14 p. 1855 - 1861
反应条件
1: 0.166667 h; 2: With sodium azide T=50°C;
参考文献
PFIZER INC.; CAMERON, Kimberly O'Keefe; KRAUSS, Achim Hans-Peter; LEFKER, Bruce Allen; NAIR, Sajiv Krishnan; PRASANNA, Ganesh; RUI, Eugene Yuanjin
Patent: WO2010/116270 A1, 2010 ;
Location in patent: Page/Page column 71-72 ;
WO 2010/116270 A1
参考文献
Du Pont de Nemours and Co.
Patent: US2603659 , 1950 ;
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; potassium hydroxide in 1,4-dioxane; water Michael condensation; 2 h; RefluxInert atmosphere;
参考文献
Horn, Joachim; Li, Ho Yin; Marsden, Stephen P.; Nelson, Adam; Shearer, Rachel J.; Campbell, Amanda J.; House, David; Weingarten, Gordon G.
Tetrahedron, 2009 , vol. 65, # 44 p. 9002 - 9007
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; potassium hydroxide in 1,4-dioxane; water Michael condensation; 2 h; RefluxInert atmosphere;
参考文献
Horn, Joachim; Li, Ho Yin; Marsden, Stephen P.; Nelson, Adam; Shearer, Rachel J.; Campbell, Amanda J.; House, David; Weingarten, Gordon G.
Tetrahedron, 2009 , vol. 65, # 44 p. 9002 - 9007
反应条件
10 Au/Co3O4; hydrogen in n-heptane T=90°C; P=33753.4 Torr; 24 h; Autoclave; ConcentrationPressureTemperature;
参考文献
Liu, Xiaohao; Hamasaki, Akiyuki; Yamane, Yoshihiro; Aikawa, Shohei; Ishida, Tamao; Haruta, Masatake; Tokunaga, Makoto
Catalysis Science and Technology, 2013 , vol. 3, # 11 p. 3000 - 3006
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in dimethyl sulfoxide T=120°C;
参考文献
Zhou, Wang; Zhang, Liangren; Jiao, Ning
Tetrahedron, 2009 , vol. 65, # 10 p. 1982 - 1987
反应条件
tri-ruthenium(0)dodecacarbonyl; tetra-(n-butyl)ammonium iodide in dimethyl sulfoxide; toluene T=20 - 120°C; 20.08 h; Sealed tube; Overall yield = 70 percentSpectr.; regioselective reaction;
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
反应条件
1: 15 percent / CH2Cl2; trifluoroacetic acid 2: 57 percent / lauroyl peroxide / chlorobenzene / Heating View Scheme
参考文献
Binot, Gregori; Zard, Samir Z.
Tetrahedron Letters, 2005 , vol. 46, # 44 p. 7503 - 7506
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / tetrahydrofuran; water / 16 h / |Reflux 2: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
