2-氯-4-乙基-5-嘧啶羰基氯化物合成路线 （共 5 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; Chlorination; 4 h;
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
反应条件
1: 81 percent / NaOEt / ethanol / 20 °C 2: POCl3 / 1 h / Heating 3: aq. NaOH / 3 h / 20 °C 4: (COCl)2; DMF / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
反应条件
1: POCl3 / 1 h / Heating 2: aq. NaOH / 3 h / 20 °C 3: (COCl)2; DMF / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
反应条件
1: aq. NaOH / 3 h / 20 °C 2: (COCl)2; DMF / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
反应条件
1: 37 percent / Heating 2: 81 percent / NaOEt / ethanol / 20 °C 3: POCl3 / 1 h / Heating 4: aq. NaOH / 3 h / 20 °C 5: (COCl)2; DMF / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
