双(3-甲基-2-噻吩基)甲酮合成路线 （共 6 条）
反应条件
pyridinium chlorochromate absorbed on neutral alumina in dichloromethane 0.75 h;
参考文献
Callen, Gary; Chorghade, Mukund S.; Lee, Elaine C.; Nielsen, Peter G.; Petersen, Hans; Rustum, Abu
Heterocycles, 1994 , vol. 39, # 1 p. 293 - 304
反应条件
1: 1.) Mg / 1.) Et2O, 1 h, 2.) Et2O, 1 h 2: 76 percent / MnO2 / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 12 p. 1716 - 1725
反应条件
1: 1.) Mg / 1.) Et2O, 1 h, 2.) Et2O, 1 h 2: 76 percent / MnO2 / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 12 p. 1716 - 1725
反应条件
1: 1.) Mg / 1.) THF, reflux, 0.5 h, 2.) THF, reflux, 1.5 h 2: 46 percent / 48percent aq. HBr / acetic acid / 1.5 h / 10 °C 3: 50 percent / KI, K2CO3 / acetone / 44 h / Ambient temperature View Scheme
参考文献
Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725
反应条件
1: 1.) Mg / 1.) THF, reflux, 0.5 h, 2.) THF, reflux, 1.5 h 2: 46 percent / 48percent aq. HBr / acetic acid / 1.5 h / 10 °C 3: 50 percent / KI, K2CO3 / acetone / 44 h / Ambient temperature 4: 12 M aq. NaOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725
反应条件
1: 1.) Mg / 1.) THF, reflux, 0.5 h, 2.) THF, reflux, 1.5 h
2: 46 percent / 48percent aq. HBr / acetic acid / 1.5 h / 10 °C
View Scheme
参考文献
Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725
