3-(三氟甲氧基)苯乙酮合成路线 （共 16 条）
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in ethyl acetate 13 h; Reflux;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h;
参考文献
Blencowe, Anton; Cosstick, Kevin; Hayes, Wayne
New Journal of Chemistry, 2006 , vol. 30, # 1 p. 53 - 58
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran Metallation; 2: N-(trifluoroacetyl)piperidine in tetrahydrofuran Acylation; 2 h;
参考文献
Stauffer, Shaun R.; Sun, Jun; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 6 p. 1293 - 1316
反应条件
1: 3-methoxybromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; 2: trifluoro acetic acid methyl ester in tetrahydrofuran; hexane T=-78°C; 2.5 h; Further stages.;
参考文献
Mayer, Timo; Maier, Martin E.
European Journal of Organic Chemistry, 2007 , # 28 p. 4711 - 4720
反应条件
tributylphosphine; palladium diacetate in 1-methyl-pyrrolidin-2-one T=80°C; 4 h;
参考文献
Kakino; Shimizu; Yamamoto
Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 2 p. 371 - 376
反应条件
in diethyl ether 2 h; Heating;
参考文献
Hartmann, Rolf W.; Heindl, Alexander; Schneider, Martin R.; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 322 - 328
反应条件
in tetrahydrofuran T=-78°C;
参考文献
Konno, Tsutomu; Takehana, Tsuyoshi; Mishima, Makoto; Ishihara, Takashi
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3545 - 3550
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2.5 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 135, # 14 p. 5364 - 5367
反应条件
1.1: tetrahydrofuran / 0.17 h / 0 °C / |Inert atmosphere; |Sealed tube 1.2: 0 - 20 °C / |Inert atmosphere; |Sealed tube 1.3: 0 - 20 °C / |Inert atmosphere; |Sealed tube 2.1: oxoammonium salt; 2,6-dimethylpyridine / dichloromethane / 20 °C / |Sealed tube View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 18 p. 8131 - 8141
反应条件
1: 99 percent / KOH / tetrahydrofuran / 16 h 2: 88 percent / n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C View Scheme
参考文献
New Journal of Chemistry, , vol. 30, # 1 p. 53 - 58
