2,3-O-异亚丙基-D-核糖酸 gamma-内酯合成路线 （共 36 条）
反应条件
1.1: carbon-supported palladium-bismuth; oxygen; potassium hydroxide / water / 1.83 h / 50 °C / pH 9 2.1: hydrogenchloride / water / 3 h / 20 °C 2.2: 4 h / 60 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 22 p. 7720 - 7726
反应条件
toluene-4-sulfonic acid 48 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 53, # 36 p. 12067 - 12088
反应条件
sulfuric acid 1 h; Ambient temperature; Yield given;
参考文献
Pharmaceutical Chemistry Journal, , vol. 16, # 2 p. 135 - 139
Khimiko-Farmatsevticheskii Zhurnal, , vol. 16, # 2 p. 196 - 201
参考文献
Canadian Journal of Chemistry, , vol. 36, p. 1720,1725
反应条件
1.1: pyridine / 4 h / -15 - 20 °C / |Inert atmosphere; |Large scale 2.1: potassium hydroxide / water / 3 h / 20 °C / |Large scale 3.1: 4-(N,N-dimethlyamino)pyridine; 1H-imidazole / N,N-dimethyl-formamide / 1 h / |Large scale 3.2: 16 h / 0 - 20 °C / |Inert atmosphere; |Large scale View Scheme
反应条件
N-bromosuccinmide; triphenylphosphine
参考文献
Jaeger, Volker; Haefele, Brigitte
Synthesis, 1987 , # 9 p. 801 - 806
反应条件
1H-imidazole in N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
Jones, Nigel A.; Jenkinson, Sarah F.; Soengas, Raquel; Fanefjord, Mette; Wormald, Mark R.; Dwek, Raymond A.; Kiran, Gullapalli P.; Devendar, Rao; Takata, Goro; Morimoto, Kenji; Izumori, Ken; Fleet, George W.J.
Tetrahedron Asymmetry, 2007 , vol. 18, # 6 p. 774 - 786
反应条件
1: 40 percent / silver oxide / dimethylformamide / 48 h / in dark 2: 80 percent / sodium borohydride / tetrahydrofuran / 55 °C / 2.) methanol 45 min and 1h 3: acetic acid; H2O / 4 h / 50 °C 4: pyridine / Ambient temperature 5: 86 percent / 1.) sodium hydride / dimethylformamide / 1.) 0 deg C 30 min; 2.) 0 deg C 30 min; 3.) room temperature overnight 6: 90 percent / acetic acid; H2O / 1.5 h / 80 °C View Scheme
参考文献
Hoogerhout, P.; Evenberg, D.; Boeckel, C. A. A. van; Poolman, J. T.; Beuvery, E. C.; et al.
Tetrahedron Letters, 1987 , vol. 28, # 14 p. 1553 - 1556
反应条件
water T=80°C; 0.25 h; microwave irradiation;
参考文献
Procopio, Antonio; Gaspari, Marco; Nardi, Monica; Oliverio, Manuela; Tagarelli, Antonio; Sindona, Giovanni
Tetrahedron Letters, 2007 , vol. 48, # 49 p. 8623 - 8627
反应条件
hydrogenchloride 1.) 60 deg C, 1 h, 2.) 80 deg C, 2 h;
参考文献
Pharmaceutical Chemistry Journal, , vol. 16, # 2 p. 135 - 139
Khimiko-Farmatsevticheskii Zhurnal, , vol. 16, # 2 p. 196 - 201
