3-溴-5-(羟基甲基)苯甲酸甲酯合成路线 （共 6 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol T=0°C; 5 h; Cooling with ice;
参考文献
TEIJIN LIMITED
Patent: EP1460059 A1, 2004 ;
Location in patent: Page 8 ;
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=65°C; 0.5 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249607 A1, 2007 ;
Location in patent: Page/Page column 85 ;
US 20070249607 A1
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol 0.5 h; Heating / reflux;
参考文献
TEIJIN LIMITED
Patent: EP1179527 A1, 2002 ;
Location in patent: Page 20 ;
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=0 - 60°C; 12.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/40568 A1, 2006 ;
Location in patent: Page/Page column 81 ;
WO 2006/040568 A1
反应条件
N-bromosuccinmide; triphenylphosphine in tetrahydrofuran
T=0 - 20°C; 16 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249607 A1, 2007 ;
Location in patent: Page/Page column 85 ;
US 20070249607 A1
反应条件
manganese(IV) dioxide in toluene
T=105°C; 7 h;
参考文献
TEIJIN LIMITED
Patent: EP1460059 A1, 2004 ;
Location in patent: Page 9-10 ;
