3-氯-5-硝基-1,2-苯异噻唑合成路线 （共 8 条）
反应条件
chlorine in acetic acid
参考文献
American Cyanamid Company
Patent: EP908457 A1, 1999 ;
反应条件
copper dichloride; isopentyl nitrite in acetonitrile T=65°C; 1 h;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2006/91858 A1, 2006 ;
Location in patent: Page/Page column 140 ;
反应条件
tributyl-amine; trichlorophosphate in dichloromethane
参考文献
Intellectual Property Department BASF Aktiengesellschaft
Patent: US2002/28748 A1, 2002 ;
反应条件
tributyl-amine; trichlorophosphate T=20 - 115°C;
参考文献
Tanikawa, Hiroharu; Ishii, Kazuhiro; Kubota, Shun; Sasanuma, Takashi; Yagai, Shiki; Kitamura, Akihide; Karatsu, Takashi
Heterocycles, 2010 , vol. 81, # 3 p. 659 - 674
反应条件
sulfuric acid; potassium nitrate
参考文献
Vitali,T. et al.
Farmaco, Edizione Scientifica, 1973 , vol. 28, p. 8 - 18
反应条件
ammonia in formamide 1.) 140-150 deg C, 2 h; 2.) 20 h;
参考文献
Vicini
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 10 p. 808 - 818
反应条件
hydrogenchloride; iron in water; toluene 0.583333 h; Heating / reflux;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2006/91858 A1, 2006 ;
Location in patent: Page/Page column 140-141 ;
反应条件
hydrogenchloride in water; ethyl acetate; toluene
参考文献
American Cyanamid Company
Patent: EP908457 A1, 1999 ;
