5-乙酰基-2-氨基-4-甲基噻唑合成路线 （共 13 条）
反应条件
isopentyl nitrite
T=70 - 80°C;
参考文献
Vernin,G.; Metzger,J.
Journal of Organic Chemistry, 1975 , vol. 40, p. 3183 - 3189
反应条件
1: 2-amino-5-acetyl-4-methyl-thiazole With sodium hydride in N,N-dimethyl-formamide
T=0°C;
2: carbonic acid diphenyl ester T=20°C; 0.5 h;
参考文献
Batt, Douglas G.
Patent: US2004/67935 A1, 2004 ;
Location in patent: Page/Page column 31 ;
US 20040067935 A1
反应条件
1: With pyridine
T=0 - 20°C; 0.166667 h;
2: With sodium hydrogencarbonate in water
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/48771 A1, 2007 ;
Location in patent: Page/Page column 50 ;
WO 2007/048771 A1
