3-[(3-三氟甲基)苯基]-5-[(4-羧基苯基)亚甲基]-2-硫代-4-噻唑烷酮合成路线 （共 3 条）
反应条件
piperidine in ethanol Knoevenagel condensation; 2 h; Reflux;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: US2011/105565 A1, 2011 ;
Location in patent: Page/Page column 28 ;
反应条件
1.1: triethylamine / ethyl acetate / Cooling with ice 2.1: sodium hydrogencarbonate / water / 2 h / pH 8 - 9 2.2: Reflux 3.1: piperidine / ethanol / 2 h / Reflux View Scheme
反应条件
1.1: triethylamine / water; tetrahydrofuran / 3.5 h / 0 - 20 °C 1.2: Reflux 2.1: piperidine / ethanol / 2 h / Reflux View Scheme
