(R)-3-氨基-3-苯基丙酸乙酯合成路线 （共 21 条）
反应条件
hydrogen; Ru(OAc)2[(S)-tol-BINAP] in ethanol T=50°C; P=22502.3 Torr; 15 h; Product distribution / selectivity;
参考文献
Takasago International Corporation
Patent: EP1386901 A1, 2004 ;
Location in patent: Page 15 ;
反应条件
hydrogen; Ru(OAc)2[(S)-tol-BINAP] in 2,2,2-trifluoroethanol T=50°C; P=22502.3 Torr; 15 h; Product distribution / selectivity;
参考文献
Takasago International Corporation
Patent: EP1386901 A1, 2004 ;
Location in patent: Page 14 ;
反应条件
hydrogen in ethanol T=50°C; P=22502.3 Torr; 15 h; Product distribution / selectivity;
参考文献
Takasago International Corporation
Patent: EP1386901 A1, 2004 ;
Location in patent: Page 15 ;
反应条件
10 Pd(OH)2/C; hydrogen in ethanol T=20°C; P=760.051 Torr; 8 h; optical yield given as percent ee;
参考文献
Wu, Xinjun; Li, Yang; Wang, Chao; Zhou, Li; Lu, Xiaoxia; Sun, Jian
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2846 - 2848
反应条件
hydrogen; palladium dihydroxide in acetic acid P=3040 Torr;
参考文献
Honda, Toshio; Wakabayashi, Hitoshi; Kanai, Kazuo
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 2 p. 307 - 308
反应条件
1: With triethylamine; trichlorophosphate in tetrahydrofuran T=0 - 20°C; Retro Strecker method; 6 h; Heating / reflux; 2: With hydroxylamine hydrochloride in tetrahydrofuran; water T=20°C; 16 h; 3: With hydrogenchloride; sodium hydroxide Product distribution / selectivity; more than 3 stages;
参考文献
DSM IP ASSETS B.V.
Patent: WO2006/69798 A1, 2006 ;
Location in patent: Page/Page column 11 ;
反应条件
1: With trimethylsilyl trifluoromethanesulfonate in dichloromethane T=-70°C; Addition; 6 h; 2: With water in dichloromethane T=20°C; Hydrolysis; 0.5 h; 3: With water; sodium hydrogencarbonate in dichloromethane T=20°C; Hydrolysis; 0.5 h;
参考文献
Kawecki, Robert
Journal of Organic Chemistry, 1999 , vol. 64, # 23 p. 8724 - 8727
反应条件
1: molecular sieves 3A / tetrahydrofuran / 4 h / 0 °C 2: RhCl(PPh3)3; Et2Zn / tetrahydrofuran; hexane / 0.17 h / 0 °C 3: 58 percent / H2 / Pd(OH)2 / acetic acid / 3040 Torr View Scheme
参考文献
Kawecki, Robert
Journal of Organic Chemistry, 1999 , vol. 64, # 23 p. 8724 - 8727
反应条件
1: RhCl(PPh3)3; Et2Zn / tetrahydrofuran; hexane / 0.17 h / 0 °C 2: 58 percent / H2 / Pd(OH)2 / acetic acid / 3040 Torr View Scheme
参考文献
Honda, Toshio; Wakabayashi, Hitoshi; Kanai, Kazuo
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 2 p. 307 - 308
反应条件
Lipase PS in water; isopropyl alcohol T=45°C; 22 h;
参考文献
Tasnadi, Gabor; Forro, Eniko; Fueloep, Ferenc
Tetrahedron Asymmetry, 2008 , vol. 19, # 17 p. 2072 - 2077
