(R)-3-氨基-3-苯基丙酸乙酯合成路线 （共 21 条）
反应条件
1: HCl 2: lipase Amano PS / aq. phosphate buffer / 15 h / pH 8.2 View Scheme
参考文献
Faulconbridge, Susan J.; Holt, Karen E.; Garcia Sevillano, Luis; Lock, Christopher J.; Tiffin, Peter D.; Tremayne, Neil; Winter, Stephen
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2679 - 2681
反应条件
1: Pb(OAc)4 / methanol; CH2Cl2 / 0.17 h / 0 °C 2: conc. aq. HCl / ethanol / 6 h / Ambient temperature View Scheme
参考文献
Mokhallalati; Pridgen
Synthetic Communications, 1993 , vol. 23, # 14 p. 2055 - 2064
反应条件
1: C16H24N2O2S; trichlorosilane / toluene / 24 h / -40 °C / Inert atmosphere 2: 10 Pd(OH)2/C; hydrogen / ethanol / 8 h / 20 °C / 760.05 Torr View Scheme
参考文献
Wu, Xinjun; Li, Yang; Wang, Chao; Zhou, Li; Lu, Xiaoxia; Sun, Jian
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2846 - 2848
反应条件
1: acetic acid / ethanol 2: C16H24N2O2S; trichlorosilane / toluene / 24 h / -40 °C / Inert atmosphere 3: 10 Pd(OH)2/C; hydrogen / ethanol / 8 h / 20 °C / 760.05 Torr View Scheme
参考文献
Wu, Xinjun; Li, Yang; Wang, Chao; Zhou, Li; Lu, Xiaoxia; Sun, Jian
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2846 - 2848
反应条件
lead(IV) acetate; boron trifluoride diethyl etherate; oxonium; zinc(II) chloride 1) ether, THF, reflux, 66 h, 2) a) MeOH, 0 deg C, b) EtOH; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Mokhallalati, Mohamed K.; Wu, Ming-Jung; Pridgen, Lendon N.
Tetrahedron Letters, 1993 , vol. 34, # 1 p. 47 - 50
参考文献
Fischer,E.; Scheibler; Groh
Chemische Berichte, 1910 , vol. 43, p. 2028
反应条件
nachfolgend Verseifung;
参考文献
Fischer,E.; Scheibler; Groh
Chemische Berichte, 1910 , vol. 43, p. 2028
反应条件
in anhydrous butyl ether T=70°C; 20 h; Inert atmosphere;
参考文献
Engstroem, Karin; Shakeri, Mozaffar; Baeckvall, Jan-E.
European Journal of Organic Chemistry, 2011 , # 10 p. 1827 - 1830
反应条件
1: / anhydrous butyl ether / 20 h / 70 °C / Inert atmosphere 2: ; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine / anhydrous butyl ether / 44 h / 80 °C View Scheme
参考文献
Engstroem, Karin; Shakeri, Mozaffar; Baeckvall, Jan-E.
European Journal of Organic Chemistry, 2011 , # 10 p. 1827 - 1830
反应条件
in anhydrous butyl ether T=70°C; 20 h; Inert atmosphere;
参考文献
European Journal of Organic Chemistry, , # 10 p. 1827 - 1830
