2-氯-4,6-二甲基吡啶合成路线 （共 9 条）
反应条件
1: With hydrogenchloride; sodium chloride; sodium nitrite in water T=-20 - 20°C; 2: With bicarbonate in water
参考文献
WO2009/130481 A1, ;
Page/Page column 126-127 ;
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethanol; water; toluene T=105°C; Suzuki-Miyaura cross-coupling reaction; 8 h; Title compound not separated from byproducts.;
参考文献
Synthesis, , # 17 p. 2855 - 2864
反应条件
1: 79 percent / POCl3 / 8 h / 135 °C 2: Na2CO3 / Pd(PPh3)4 / toluene; H2O; ethanol / 8 h / 105 °C View Scheme
参考文献
Synthesis, , # 17 p. 2855 - 2864
反应条件
1: Br2; acetic acid / 1 h 2: 79 percent / POCl3 / 8 h / 135 °C 3: Na2CO3 / Pd(PPh3)4 / toluene; H2O; ethanol / 8 h / 105 °C View Scheme
参考文献
Synthesis, , # 17 p. 2855 - 2864
参考文献
Journal of the Chemical Society, , vol. 71, p. 303
Chemische Berichte, , vol. 20, p. 446
反应条件
potassium permanganate; water
参考文献
Aston; Collie
Journal of the Chemical Society, 1897 , vol. 71, p. 653,655
反应条件
bei der Zinkstaub-Destillation;
参考文献
Proceedings of the Chemical Society, London, p. 175,44
反应条件
potassium permanganate; water
参考文献
Aston; Collie
Journal of the Chemical Society, 1897 , vol. 71, p. 653,655
反应条件
in diethylene glycol dimethyl ether
T=160°C; 36.5 h;
参考文献
F2G LTD
Patent: WO2009/130481 A1, 2009 ;
Location in patent: Page/Page column 127 ;
