4-(吡啶-4-基氧基)哌啶-1-羧酸叔丁酯合成路线 （共 4 条）
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6562978 B1, 2003 ;
反应条件
1: 4-chloro pyridine hydrochloride With sodium hydride in dimethyl sulfoxide T=70°C; 0.916667 h; Inert atmosphere; 2: 1-(tert-Butyloxycarbonyl)-4-piperidinol in dimethyl sulfoxide T=20°C; Inert atmosphere;
参考文献
Bailey, James M.; Bruton, Gordon; Huxley, Anthony; Johnstone, Vicky; Milner, Peter H.; Orlek, Barry S.; Stemp, Geoffrey
Synlett, 2009 , # 7 p. 1051 - 1054
反应条件
potassium carbonate in dimethyl sulfoxide T=70°C; 3 h; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/14571 A1, 2005 ;
Location in patent: Page/Page column 16 ;
WO 2005/014571 A1
反应条件
hydrogen; toluene-4-sulfonic acid; platinum(IV) oxide in ethanol
T=20°C; 14 h;
参考文献
SCHERING CORPORATION
Patent: WO2009/45313 A2, 2009 ;
Location in patent: Page/Page column 43-44 ;
WO 2009/045313 A2
