2-甲基-5-(2-氧代-1,3,3a,4,6,6a-六氢噻吩并[3,4-d]咪唑-6-基)戊酸合成路线 （共 3 条）
反应条件
trifluoroacetic acid in water T=95 - 100°C; 12 h;
参考文献
Dixon, Richard W.; Radmer, Randall J.; Kuhn, Bernd; Kollman, Peter A.; Yang, Jaemoon; Raposo, Cesar; Wilcox, Craig S.; Klumb, Lisa A.; Stayton, Patrick S.; Behnke, Craig; Le Trong, Isolde; Stenkamp, Ronald
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1827 - 1837
反应条件
1: 75 percent / H2SO4 / 17 h / Heating 2: 64 percent / KHMDS; TMEDA; HMPA / tetrahydrofuran; toluene / 1.5 h / -78 °C 3: 62 percent / TFA / H2O / 12 h / 95 - 100 °C View Scheme
参考文献
Dixon, Richard W.; Radmer, Randall J.; Kuhn, Bernd; Kollman, Peter A.; Yang, Jaemoon; Raposo, Cesar; Wilcox, Craig S.; Klumb, Lisa A.; Stayton, Patrick S.; Behnke, Craig; Le Trong, Isolde; Stenkamp, Ronald
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1827 - 1837
反应条件
1: 64 percent / KHMDS; TMEDA; HMPA / tetrahydrofuran; toluene / 1.5 h / -78 °C 2: 62 percent / TFA / H2O / 12 h / 95 - 100 °C View Scheme
参考文献
Dixon, Richard W.; Radmer, Randall J.; Kuhn, Bernd; Kollman, Peter A.; Yang, Jaemoon; Raposo, Cesar; Wilcox, Craig S.; Klumb, Lisa A.; Stayton, Patrick S.; Behnke, Craig; Le Trong, Isolde; Stenkamp, Ronald
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1827 - 1837
