4-甲氧基-2-甲基苯乙酸甲酯合成路线 （共 6 条）
反应条件
1: 4-methoxy-2-methyl-benzoic acid With thionyl chloride 2 h; Heating / reflux; 2: diazomethane With silver benzoate; triethylamine in methanol; diethyl ether; toluene T=0 - 60°C; 19 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/63155 A1, 2004 ;
Location in patent: Page 56-57 ;
WO 2004/063155 A1
反应条件
silver benzoate; triethylamine in methanol T=60°C; 1 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/63184 A1, 2004 ;
Location in patent: Page 52 ;
WO 2004/063184 A1
反应条件
silver benzoate; triethylamine T=60°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66136 A1, 2005 ;
Location in patent: Page/Page column 50-51 ;
WO 2005/066136 A1
反应条件
methanol; sulfuric acid
参考文献
Hudson; Walton
Journal of the Chemical Society, 1946 , p. 85
反应条件
(i) Mor, sulfur, (ii) aq. NaOH, EtOH, (iii) /BRN= 1098229/, H2SO4; Multistep reaction;
参考文献
Ghatak,U.R.; Chatterjee,N.R.
Journal of the Chemical Society [Section] C: Organic, 1971 , p. 190 - 196
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Ghatak,U.R.; Chatterjee,N.R.
Journal of the Chemical Society [Section] C: Organic, 1971 , p. 190 - 196
