4-(4-溴苯基)-4-氧代丁酸甲酯合成路线 （共 23 条）
反应条件
sulfuric acid in methanol Reflux;
参考文献
Daito Chemix Corporation; Kyoto University; KAKIZUKA, Akira; HORI, Seiji; IKEDA, Hanako; YOSHIMURA, Nagahisa; NAKANO, Noriko; SHUDO, Toshiyuki; FUCHIGAMI, Tomohiro
Patent: EP2623494 A1, 2013 ;
Location in patent: Paragraph 0175-0176 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=25°C; Inert atmosphere;
参考文献
Li, Wei-Shi; Yamamoto, Yohei; Fukushima, Takanori; Saeki, Akinori; Seki, Shu; Tagawa, Seiichi; Masunaga, Hiroyasu; Sasaki, Sono; Takata, Masaki; Aida, Takuzo
Journal of the American Chemical Society, 2008 , vol. 130, # 28 p. 8886 - 8887
反应条件
3-methyl-2-amino-pyridine; benzoic acid; Wilkinson's catalyst in toluene T=130°C; 2 h;
参考文献
Jo, Eun-Ae; Jun, Chul-Ho
European Journal of Organic Chemistry, 2006 , # 11 p. 2504 - 2507
反应条件
palladium diacetate; triethylamine in tetrahydrofuran 8 h; Heating;
参考文献
Sierra; Del Amo; Mancheno; Gomez-Gallego
Journal of the American Chemical Society, 2001 , vol. 123, # 5 p. 851 - 861
反应条件
1: With sulfuric acid 1 h; Inert atmosphereReflux; 2: With potassium carbonate in methanol 0.5 h; Cooling with ice;
参考文献
Kallemeyn, Jeffrey M.; Mulhern, Mathew M.; Ku, Yi-Yin
Synlett, 2011 , # 4 p. 535 - 538
反应条件
palladium diacetate; triethylamine in tetrahydrofuran Heating;
参考文献
Sierra; Mancheno; Saez; Del Amo
Journal of the American Chemical Society, 1998 , vol. 120, # 27 p. 6812 - 6813
反应条件
1: With AlCl3, aluminium chloride T=0 - 80°C; Friedel-Crafts Acylation; 4 h; 2: With hydrogenchloride Cooling with ice;
参考文献
Sun, Wei; Tian, Linjie; Qi, Hui; Jiang, Dan; Wang, Ying; Li, Song; Xiao, Junhai; Yang, Xiaohong
Chinese Journal of Chemistry, 2013 , vol. 31, # 9 p. 1144 - 1152
反应条件
1: With Grubb's 2nd generation catalyst in toluene T=110°C; 0.5 h; Inert atmosphere; 2: in toluene T=130°C; 12 h; Reagent/catalyst;
参考文献
Schmidt, Bernd; Hauke, Sylvia
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 25 p. 4194 - 4206
反应条件
Oxonereg; T=20°C; 18 h;
参考文献
Travis, Benjamin R.; Sivakumar, Meenakshi; Hollist, G. Olatunji; Borhan, Babak
Organic Letters, 2003 , vol. 5, # 7 p. 1031 - 1034
反应条件
aluminium trichloride in dichloromethane; chloroform; water
参考文献
Warner-Lambert Company
Patent: US6399612 B1, 2002 ;
