1,3-二环丙基-1,3-丙二酮合成路线 （共 5 条）
反应条件
1: With ethanol; sodium hydride in tetrahydrofuran T=20°C; Inert atmosphere; 2: With 18-crown-6 ether T=40°C; 3 h;
参考文献
ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta
Patent: WO2013/10880 A1, 2013 ;
Location in patent: Page/Page column 161 ;
反应条件
1: With sodium methylate in dimethyl sulfoxide T=55°C; 8 h; 2: With hydrogenchloride in water; dimethyl sulfoxide; toluene
参考文献
Pfizer Inc.
Patent: US2007/105909 A1, 2007 ;
Location in patent: Page/Page column 17 ;
US 20070105909 A1
参考文献
Yoshida,Z.; Ogoshi,H.
Tetrahedron, 1970 , vol. 26, p. 4691 - 4696
反应条件
1: With chloro-trimethyl-silane in dichloromethane
T=20°C; 0.75 h;
2: With N-chloro-succinimide in dichloromethane
T=10 - 20°C; 0.5 h; Product distribution / selectivity;
参考文献
Gibson, Karl Richard; Skerratt, Sarah Elizabeth; Dack, Kevin Neil
Patent: US2008/96950 A1, 2008 ;
Location in patent: Page/Page column 17 ;
US 20080096950 A1
反应条件
chloro-trimethyl-silane; tetrabutylammomium bromide; dimethyl sulfoxide in acetonitrile
T=0 - 20°C; 18 h;
参考文献
Pfizer Inc.
Patent: US2007/105909 A1, 2007 ;
Location in patent: Page/Page column 18 ;
US 20070105909 A1
