N-叔丁氧羰基-L-谷氨酸 1-苄酯合成路线 （共 26 条）
反应条件
ethylenediaminetetraacetic acid; D,L-Cysteine; papain in dichloromethane T=37°C; 8 h;
参考文献
Cantacuzene, D.; Pascal, F.; Guerreiro, C.
Tetrahedron, 1987 , vol. 43, # 8 p. 1823 - 1826
反应条件
sodium hydroxide in 1,4-dioxane 0.5 h;
参考文献
Sturtz; Appere; Breistol; Fodstad; Schwartsmann; Hendriks
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 8 p. 825 - 833
反应条件
1: DL-glutamic acid; benzyl chloroformate With sodium hydroxide in water; toluene 2: toluene-4-sulfonic acid in benzene Heating; 3: With sodium hydroxide in 1,4-dioxane; water Further stages.;
参考文献
Chemical communications (Cambridge, England), , # 19 p. 1908 - 1909
反应条件
N,N,N',N'-tetramethylguanidine in N,N-dimethyl-formamide
参考文献
Angewandte Chemie, , vol. 84, p. 259
参考文献
Justus Liebigs Annalen der Chemie, , vol. 673, p. 196 - 207
反应条件
1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0.5 h / 0 - 20 °C / |Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Usuki, Toyonobu; Sugimura, Takanori; Komatsu, Akira; Koseki, Yohei
Organic Letters, 2014 , vol. 16, # 6 p. 1672 - 1675
反应条件
1: 1.) N-hydroxybenzotriazole (HOBt), 4-methylmorpholine (NMM), 2.) dicyclohexylcarbodiimide (DCC) / 1.) CH2Cl2 (DCM), 0 deg C, 2.) a) 0 deg C, 1 h, b) RT 2: H2 / Pd-C:BaSO4 / dimethylformamide; methanol; H2O / 3 h / 1551.4 Torr 3: 48percent trifluoroacetic acid, 2percent anisole / CH2Cl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Al-Obeidi; Mulcahy; Pitt; Begay; Hadley; Hruby
Journal of Pharmaceutical Sciences, 1990 , vol. 79, # 6 p. 500 - 504
反应条件
1: 4-(N,N-dimethlyamino)pyridine; n-butyllithium; dicyclohexyl-carbodiimide / dichloromethane; ethyl acetate; tetrahydrofuran 2: boron trifluoride / tetrahydrofuran View Scheme
参考文献
Petter, Russell C.; Jewell, Charles F.; Lee, Kwangho; Medikonda, Aravind Prasad; Niu, Deqiang; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong
Patent: US2011/269244 A1, 2011 ;
反应条件
4-(N,N-dimethlyamino)pyridine; n-butyllithium; dicyclohexyl-carbodiimide in tetrahydrofuran; dichloromethane; ethyl acetate
参考文献
Petter, Russell C.; Jewell, Charles F.; Lee, Kwangho; Medikonda, Aravind Prasad; Niu, Deqiang; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong
Patent: US2011/269244 A1, 2011 ;
Location in patent: Page/Page column ;
反应条件
2: 1 N HCl, H2O / acetic acid / 0.83 h / 55 °C View Scheme
参考文献
Noda, Kosaku; Gross, Erhard
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1981 , vol. 36, # 10 p. 1345 - 1348
