N-叔丁氧羰基-L-谷氨酸 1-苄酯合成路线 （共 26 条）
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in dichloromethane
Substitution;
参考文献
Cordova, Armando; Reed, Neal N.; Ashley, Jon A.; Janda, Kim D.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 21 p. 3119 - 3122
反应条件
dicyclohexyl-carbodiimide in 1,4-dioxane; ethyl acetate
1.) 1 h, 0 deg C, 2.) 3 h, room temperature;
参考文献
Gisin, B.F.; Davis, D.G.; Borowska, Z.K.; Hall, J.E.; Kobayashi, S.
Journal of the American Chemical Society, 1981 , vol. 103, # 21 p. 6373 - 6377
反应条件
1: 1.) N-methylmorpholine, isobutylchloroformate, 2.) triethylamine / 1.) THF, -15 deg C, 5 min, 2.) THF, -15 deg C, 20 min
2: tetrahydrofuran / 0.33 h / Irradiation
3: 100 percent / NaOH / dioxane; H2O / 0.5 h / Ambient temperature
View Scheme
参考文献
Barton, Derek H. R.; Bridon, Dominique; Herve, Yolande; Potier, Pierre; Thierry, Josiane; Zard, Samir Z.
Tetrahedron, 1986 , vol. 42, # 18 p. 4983 - 4990
反应条件
1: 70 percent / EDC / CH2Cl2 / 20 h / Ambient temperature
2: HCOOH, 30percent H2O2 / 20 h / Ambient temperature
3: H2, 98percent aq. HCOOH, 30percent H2O2 / 10percent Pd/C / 10 h
View Scheme
参考文献
Higashiura; Ienaga
Synthesis, 1992 , # 4 p. 353 - 354
反应条件
lithium borohydride; formic acid
1.) THF, room temperature, 16 h, 2.) room temperature, 4 h.; Yield given. Multistep reaction;
参考文献
Ishida, Keishi; Matsuda, Hisashi; Murakami, Masahiro
Tetrahedron, 1998 , vol. 54, # 21 p. 5545 - 5556
反应条件
1: 92 percent / EDC / CH2Cl2
2: 84 percent / NaBH4 / tetrahydrofuran / 24 h / 4 °C
3: 99 percent / TEA / CH2Cl2 / 3 h / -20 °C
4: 99 percent / TFA / CH2Cl2 / 3 h / 20 °C
5: 96 percent / triethylammonium carbonate buffer / dimethylformamide / 0.17 h / 20 °C / pH 8.4
View Scheme
参考文献
Cordova, Armando; Reed, Neal N.; Ashley, Jon A.; Janda, Kim D.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 21 p. 3119 - 3122
