(甲基{[(2-甲基-2-丙基)氧基]羰基}氨基)(苯基)乙酸合成路线 （共 7 条）
反应条件
sodium hydride in tetrahydrofuran 16 h; Ambient temperature;
参考文献
Corringer; Weng; Ducos; Durieux; Boudeau; Bohme; Roques
Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 166 - 172
反应条件
1: di-tert-butyl dicarbonate; (S)-2-phenylglycine 2: methyl iodide With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; VERKMAN, Alan
Patent: WO2009/51910 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
WO 2009/051910 A1
反应条件
sec.-butyllithium; (-)-sparteine in tetrahydrofuran T=-75°C; var. solvents; other electrophiles; Product distribution;
参考文献
Voyer, Normand
Tetrahedron Letters, 1995 , vol. 36, # 37 p. 6627 - 6630
反应条件
1: 1.) sec-butyllithium, 2.) (-)-sparteine 2: 0.6 M methanolic KOH / 0.5 h / 65 °C View Scheme
参考文献
Schlosser, Manfred; Limat, Dominique
Journal of the American Chemical Society, 1995 , vol. 117, # 49 p. 12342 - 12343
反应条件
sec.-butyllithium; (-)-sparteine in diethyl ether T=-78°C; 1.) 3 h; 2.) 50 min; Yield given. Yields of byproduct given;
参考文献
Voyer, Normand
Tetrahedron Letters, 1995 , vol. 36, # 37 p. 6627 - 6630
反应条件
1: triethylamine / dioxane; H2O / 4 h / Ambient temperature 2: NaH / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Kajiyama, Shin-Ichiro; Irie, Kazuhiro; Kido, Takae; Koshimizu, Koichi; Hayashi, Hideo; Arai, Motoo
Tetrahedron, 1991 , vol. 47, # 29 p. 5453 - 5462
反应条件
1: triethylamine / dioxane; H2O / 4 h / Ambient temperature 2: NaH / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Kajiyama, Shin-Ichiro; Irie, Kazuhiro; Kido, Takae; Koshimizu, Koichi; Hayashi, Hideo; Arai, Motoo
Tetrahedron, 1991 , vol. 47, # 29 p. 5453 - 5462
