1-甲基-2-氧代吡咯烷-3-羧酸合成路线 （共 3 条）
反应条件
1: With anhydrous potassium trimethylsilanolate in tetrahydrofuran T=20°C; 2: With hydrogenchloride in tetrahydrofuran; diethyl ether 0.0833333 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.
Patent: WO2007/146824 A2, 2007 ;
Location in patent: Page/Page column 154 ;
WO 2007/146824 A2
反应条件
5 Pd(II)/C(eggshell); hydrogen in ethyl acetate 2 h;
参考文献
Moody, Catherine L.; Franckevicius, Vilius; Drouhin, Pauline; Klein, Johannes E.M.N.; Taylor, Richard J.K.
Tetrahedron Letters, 2012 , vol. 53, # 15 p. 1897 - 1899
反应条件
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere 1.2: 1 h / -78 °C / Inert atmosphere 2.1: 5 Pd(II)/C(eggshell); hydrogen / ethyl acetate / 2 h View Scheme
参考文献
Moody, Catherine L.; Franckevicius, Vilius; Drouhin, Pauline; Klein, Johannes E.M.N.; Taylor, Richard J.K.
Tetrahedron Letters, 2012 , vol. 53, # 15 p. 1897 - 1899
