乙基1-甲基-2-氧代-3-吡咯烷羧酸酯合成路线 （共 4 条）
反应条件
sodium hydride in toluene 8 h; Heating;
参考文献
Loreto, M. Antonietta; Migliorini, Antonella; Tardella, P. Antonio; Gambacorta, Augusto
European Journal of Organic Chemistry, 2007 , # 14 p. 2365 - 2371
反应条件
1: With anhydrous potassium trimethylsilanolate in tetrahydrofuran
T=20°C;
2: With hydrogenchloride in tetrahydrofuran; diethyl ether
0.333333 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.
Patent: WO2007/146824 A2, 2007 ;
Location in patent: Page/Page column 155 ;
WO 2007/146824 A2
反应条件
1: 80 percent / NaBH4; CaCl2 / methanol / 14 h / 20 °C
2: 52 percent / N,N-dicyclohexylcarbodiimide; CuI / toluene / 1.17 h / Heating
View Scheme
参考文献
Loreto, M. Antonietta; Migliorini, Antonella; Tardella, P. Antonio; Gambacorta, Augusto
European Journal of Organic Chemistry, 2007 , # 14 p. 2365 - 2371
反应条件
sodium tetrahydroborate; calcium chloride in methanol
T=20°C; 14 h;
参考文献
Loreto, M. Antonietta; Migliorini, Antonella; Tardella, P. Antonio; Gambacorta, Augusto
European Journal of Organic Chemistry, 2007 , # 14 p. 2365 - 2371
