4-溴-5-甲氧基吲哚-2-羧酸乙酯合成路线 (共 7 条)
反应条件
bromine in acetic acid 24 h; Ambient temperature;
参考文献
Kruse; Meyer
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4761 - 4768
反应条件
boron trifluoride diethyl etherate in chloroform 20 h; Heating;
参考文献
Hino; Hasegawa; Liu; Nakagawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 1 p. 59 - 64
反应条件
hydrogen bromide in acetic acid 24 h; Ambient temperature;
参考文献
Kruse; Meyer
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4761 - 4768
反应条件
bromine in acetic acid 1 h; Ambient temperatureother methoxy derivatives of ethyl indole-2-acrboxylate; pyridinium bromide perbromide or N-bromosuccinimide (NBS) as bromination agent; var. solvents, temperatures and reaction times; Product distributionMechanism;
参考文献
Tani, Masanobu; Ikegami, Hiroyo; Tashiro, Mayumi; Hiura, Tetsuji; Tsukioka, Hiroko; et al.
Heterocycles, 1992 , vol. 34, # 12 p. 2349 - 2362
反应条件
bromine in acetic acid 0.00277778 h; 30 s, 24 h or 24 h with sodium acetate buffer; Product distribution;
参考文献
Kruse; Meyer
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4761 - 4768
反应条件
1: 1.) LiAlH4 / tetrahydrofuran / 0 °C / 1.) 15 min, 2.) 45 min
2: MnO2 / CH2Cl2 / 1 h / 25 °C
3: 95 percent / Rh(dppp)2Cl / 18 h / Heating
View Scheme
参考文献
Meyer; Kruse
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3195 - 3199
反应条件
sodium hydroxide in tetrahydrofuran; ethanol
1 h; Heating;
参考文献
Kruse; Meyer
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4761 - 4768