4-硝基-3,5-二甲基苯甲酸合成路线 （共 27 条）
反应条件
1: (i) PCl5, (ii) aq. NH3 2: aq. NaOH, Br2 3: (i) aq. HCl, NaNO2, (ii) HPF6 4: H2 / Pd-C 5: (i) aq. HCl, NaNO2, (ii) CuCl, aq. HCl View Scheme
参考文献
Dewar,M.J.S.; Takeuchi,Y.
Journal of the American Chemical Society, 1967 , vol. 89, # 2 p. 390 - 394
反应条件
1: 75 percent / NaBH4, BF3 etherate / tetrahydrofuran
2: 90 percent / ceric ammonium nitrate / acetic acid / 0.5 h / Heating
3: 85 percent / formic acid (90percent), acetic anhydride / 3 h / Heating
4: NaOH, zinc dust / H2O; ethanol / 1 h / Heating
5: 78 percent / ammonium acetate, potassium ferricyanide / H2O; tetrahydrofuran / 240 h / 45 °C
6: 75 percent / ascorbic acid / H2O; methanol
View Scheme
参考文献
Goldstein, Stephen L.; McNelis, Edward
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1613 - 1620
反应条件
1: 75 percent / NaBH4, BF3 etherate / tetrahydrofuran
2: 64 percent / NaOH, zinc dust / ethanol; H2O / 1 h / Heating
View Scheme
参考文献
Goldstein, Stephen L.; McNelis, Edward
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1613 - 1620
反应条件
1: 75 percent / NaBH4, BF3 etherate / tetrahydrofuran
2: 90 percent / ceric ammonium nitrate / acetic acid / 0.5 h / Heating
3: 85 percent / formic acid (90percent), acetic anhydride / 3 h / Heating
4: NaOH, zinc dust / H2O; ethanol / 1 h / Heating
View Scheme
参考文献
Goldstein, Stephen L.; McNelis, Edward
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1613 - 1620
反应条件
1: 75 percent / NaBH4, BF3 etherate / tetrahydrofuran
2: PBr3 / diethyl ether
3: methanol / 5 h / Heating
4: 1.) NaOH, zinc dust 2.) HCl / 1.) water, ethanol, 1 h reflux 2.) Et2O, -50 deg C
View Scheme
参考文献
Goldstein, Stephen L.; McNelis, Edward
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1613 - 1620
反应条件
1: 82 percent / SOCl2 / 3 h / Heating
2: 78 percent / AlCl3 / 1 h / Heating
View Scheme
参考文献
Goldstein, Stephen L.; McNelis, Edward
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1613 - 1620
反应条件
1: 82 percent / SOCl2 / 3 h / Heating
2: 78 percent / AlCl3 / 1 h / Heating
3: 60 percent / NaBH4 / ethanol / 0.5 h / Heating
4: 80 percent / H2, conc. HCl / 10percent Pd/C / ethanol
View Scheme
参考文献
Goldstein, Stephen L.; McNelis, Edward
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1613 - 1620
