2-羟基-2-(3-溴苯基)丙烷合成路线 （共 15 条）
反应条件
in diethyl ether T=0 - 20°C; 4 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2008/25509 A1, 2008 ;
Location in patent: Page/Page column 50 ;
反应条件
1: in tetrahydrofuran; diethyl ether T=6 - 20°C; 3.66667 h; 2: With hydrogenchloride in tetrahydrofuran; diethyl ether; water T=0°C;
参考文献
ELAN PHARMACEUTICALS, INC.; PHARMACIA and UP JOHN COMPANY
Patent: WO2005/95326 A2, 2005 ;
Location in patent: Page/Page column 189-190 ;
WO 2005/095326 A2
参考文献
Richardson, William H.; Stiggal-Estberg, Diana L.
Journal of the American Chemical Society, 1982 , vol. 104, # 15 p. 4173 - 4179
反应条件
1: methyl iodide With magnesium in diethyl ether Reflux; 2: (3-bromophenyl)acetic acid methyl ester in diethyl ether 3 h; Reflux;
参考文献
SANOFI; ARNAUD, Joëlle; ARTIAGA, Martine; BARTH, Francis; HORTALA, Laurent; MARTINEZ, Serge; ROUX, Pascale
Patent: WO2013/87643 A1, 2013 ;
Location in patent: Page/Page column 15 ;
反应条件
diethyl ether; methylmagnesium bromide
参考文献
Journal of the American Chemical Society, , vol. 76, p. 5380,5383
Journal of the American Chemical Society, , vol. 77, p. 3763,3764
反应条件
methyl-magnesium iodide; diethyl ether
参考文献
Journal of the American Chemical Society, , vol. 79, p. 1906,1909
参考文献
Hartsel, Joshua A.; Craft, Derek T.; Chen, Qiao-Hong; Ma, Ming; Carlier, Paul R.
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3127 - 3133
反应条件
1: sulfuric acid / benzene / Reflux 2: tetrahydrofuran / -5 - 0 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 22, # 10 p. 1215 - 1218
反应条件
in tetrahydrofuran T=-5 - 0°C;
参考文献
Chinese Chemical Letters, , vol. 22, # 10 p. 1215 - 1218
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane; water T=-60°C; 0.333333 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane 0.833333 h;
参考文献
Sagara, Takeshi; Otsuki, Sachie; Sunami, Satoshi; Sakamoto, Toshihiro; Niiyama, Kenji; Yamamoto, Fuyuki; Yoshizumi, Takashi; Furuyama, Hidetomo; Goto, Yasuhiro; Bamba, Makoto; Takahashi, Keiji; Hirai, Hiroshi; Nishibata, Toshihide
Patent: US2007/254892 A1, 2007 ;
Location in patent: Page/Page column 42 ;
US 20070254892 A1
