2-苯并[b]噻吩-2-乙醇合成路线 （共 8 条）
反应条件
1: benzo[b]thiophene With n-butyllithium in tetrahydrofuran; diethyl ether; hexane T=-78°C; 2 h; 2: oxirane in tetrahydrofuran; diethyl ether; hexane T=-78 - 20°C; 17.25 h;
参考文献
ALLERGAN, INC.
Patent: US2006/106088 A1, 2006 ;
Location in patent: Page/Page column 18; sheet 5 ;
US 20060106088 A1
反应条件
1: benzo[b]thiophene in tetrahydrofuran; hexanes T=-50 - -40°C; 0.75 h; 2: ethylene glycol cyclic sulfate in tetrahydrofuran; hexanes T=-40 - 20°C; 3: With acetyl chloride in methanol T=20°C; 4.25 h;
参考文献
Neurocrine Biosciences, Inc.
Patent: US2006/14797 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
diethyl ether unter Stickstoff;
参考文献
Capps; Hamilton
Journal of the American Chemical Society, 1953 , vol. 75, p. 697
反应条件
1.1: Cu; quinoline / 240 °C 2.1: BuLi / diethyl ether 2.2: -10 °C View Scheme
参考文献
Kennis, Ludo E.J.; Bischoff, Francois P.; Mertens, Carolus J.; Love, Christopher J.; Van den Keybus, Frans A.F.; Pieters, Serge; Braeken, Mirielle; Megens, Anton A.H.P.; Leysen, Josee E.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 1 p. 71 - 74
反应条件
1.1: NaOH / 20 °C 2.1: Cu; quinoline / 240 °C 3.1: BuLi / diethyl ether 3.2: -10 °C View Scheme
参考文献
Kennis, Ludo E.J.; Bischoff, Francois P.; Mertens, Carolus J.; Love, Christopher J.; Van den Keybus, Frans A.F.; Pieters, Serge; Braeken, Mirielle; Megens, Anton A.H.P.; Leysen, Josee E.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 1 p. 71 - 74
反应条件
1.1: K2CO3 / dimethylformamide 2.1: NaOH / 20 °C 3.1: Cu; quinoline / 240 °C 4.1: BuLi / diethyl ether 4.2: -10 °C View Scheme
参考文献
Kennis, Ludo E.J.; Bischoff, Francois P.; Mertens, Carolus J.; Love, Christopher J.; Van den Keybus, Frans A.F.; Pieters, Serge; Braeken, Mirielle; Megens, Anton A.H.P.; Leysen, Josee E.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 1 p. 71 - 74
反应条件
in tetrahydrofuran; diethyl ether T=-70 - 20°C; 1 h;
参考文献
Shevchenko, Nikolay E.; Nenajdenko, Valentine G.; Balenkova, Elizabeth S.
Synthesis, 2003 , # 8 p. 1191 - 1200
反应条件
1: thionyl chloride 2: acetone; sodium iodide 4: hydrazine hydrate; chloroform; ethanol View Scheme
参考文献
Capps; Hamilton
Journal of the American Chemical Society, 1953 , vol. 75, p. 697
