(2S,3R)-3-(3'-十二烷基苯基)-2,3-二羟基丙酸乙酯合成路线 （共 5 条）
反应条件
methanesulfonamide; AD-mix-β in water; tert-butyl alcohol T=20°C; Sharpless asymmetric dihydroxylation;
参考文献
Chun, Jiong; He, Linli; Byun, Hoe-Sup; Bittman, Robert
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7634 - 7640
反应条件
1: 84 percent / tetrahydrofuran / 3 h / 0 °C 2: 85 percent / Me3SiCl; NaI / acetonitrile; hexane / 48 h / 20 °C 3: 92 percent / Et3N / (Ph3P)4Pd / dimethylformamide / 6 h / 120 °C 4: 90 percent / AD-mix-β; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 20 °C View Scheme
参考文献
Chun, Jiong; He, Linli; Byun, Hoe-Sup; Bittman, Robert
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7634 - 7640
反应条件
1: 92 percent / Et3N / (Ph3P)4Pd / dimethylformamide / 6 h / 120 °C 2: 90 percent / AD-mix-β; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 20 °C View Scheme
参考文献
Chun, Jiong; He, Linli; Byun, Hoe-Sup; Bittman, Robert
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7634 - 7640
反应条件
1: 84 percent / tetrahydrofuran / 3 h / 0 °C 2: 85 percent / Me3SiCl; NaI / acetonitrile; hexane / 48 h / 20 °C 3: 92 percent / Et3N / (Ph3P)4Pd / dimethylformamide / 6 h / 120 °C 4: 90 percent / AD-mix-β; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 20 °C View Scheme
参考文献
Chun, Jiong; He, Linli; Byun, Hoe-Sup; Bittman, Robert
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7634 - 7640
反应条件
1: 85 percent / Me3SiCl; NaI / acetonitrile; hexane / 48 h / 20 °C 2: 92 percent / Et3N / (Ph3P)4Pd / dimethylformamide / 6 h / 120 °C 3: 90 percent / AD-mix-β; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 20 °C View Scheme
参考文献
Chun, Jiong; He, Linli; Byun, Hoe-Sup; Bittman, Robert
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7634 - 7640
