N-叔丁氧羰基-2-甲基丙氨酸合成路线 （共 23 条）
反应条件
sodium hydroxide; triethylamine in 1,4-dioxane 40 h; Ambient temperature;
参考文献
Kondo; Kimura; Sato; Horimoto
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 4 p. 1391 - 1397
反应条件
1: With lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=20°C; 12 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water
参考文献
HYUNDAI PHARM CO., LTD.; LEE, Inhee; PYEON, Doohyeok; SHIN, Myounghyeon; HWANG, Jeongun; PARK, Changmin; KIM, Sehoan; CHAE, Heeil; MOON, Soonyoung; KIM, Soyoun; RHEE, Jaekeol
Patent: WO2013/19091 A2, 2013 ;
Location in patent: Paragraph 613-615 ;
WO 2013/019091 A2
反应条件
sodium hydroxide in tetrahydrofuran T=20°C;
参考文献
Principia Biopharma Inc.; Goldstein, David Michael
Patent: US8673925 B1, 2014 ;
Location in patent: Page/Page column 253 ;
反应条件
sodium hydroxide in water; tert-butyl alcohol
参考文献
Smithkline Beckman Corporation
Patent: US4876243 A1, 1989 ;
US 4876243 A
反应条件
triethylamine in 1,4-dioxane; water 18 h;
参考文献
Camphausen, Kevin; Sproull, Mary; Tantama, Steve; Venditto, Vincent; Sankineni, Sandeep; Scott, Tamalee; Brechbiel, Martin W.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 19 p. 5133 - 5140
反应条件
sodium hydroxide in water
反应条件
hydrogen; palladium on activated charcoal
参考文献
Leibfritz, Dieter; Haupt, Erhard; Dubischar, Norbert; Lachmann, Heinrich; Oekonomopulos, Raymond; Jung, Guenther
Tetrahedron, 1982 , vol. 38, # 14 p. 2165 - 2182
反应条件
sodium hydroxide in 1,4-dioxane; ethylene glycol dimethyl ether
参考文献
Frerot, Eric; Coste, Jacques; Pantaloni, Antoine; Dufour, Marie-Noelle; Jouin, Patrick
Tetrahedron, 1991 , vol. 47, # 2 p. 259 - 270
反应条件
1: 40 percent / triethylamine 2: 40 percent / OH(-) View Scheme
参考文献
Tetrahedron, , vol. 38, # 14 p. 2165 - 2182
参考文献
Leibfritz, Dieter; Haupt, Erhard; Dubischar, Norbert; Lachmann, Heinrich; Oekonomopulos, Raymond; Jung, Guenther
Tetrahedron, 1982 , vol. 38, # 14 p. 2165 - 2182
