1: tert-butyl (3S)-1-(trifluoroacetyl)piperidinylcarbamate With sodium hydride in tetrahydrofuran T=0°C; 0.333333 h; 2: methyl iodide in tetrahydrofuran T=0 - 20°C; 4 h; 3: With potassium carbonate in methanol T=20°C; 16 h;

hydrogen; palladium 10 on activated carbon in methanol 2 h;

1.1: triethylamine / dichloromethane / 0 - 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 0 °C 2.2: 4 h / 20 °C 3.1: hydrogen / palladium 10 on activated carbon / methanol / 2 h View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 0 °C 1.2: 4 h / 20 °C 2.1: hydrogen / palladium 10 on activated carbon / methanol / 2 h View Scheme