5-氨基-1-甲基吡唑-4-甲酸乙酯合成路线 （共 23 条）
参考文献
Ferring B.V.
Patent: EP1512687 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium sulfate in ethanol
参考文献
Eli Lilly and Company
Patent: US4620865 A1, 1986 ;
反应条件
in ethanol 12 h; Heating;
参考文献
Kopp; Lancelot; Dallemagne; Rault
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1045 - 1050
参考文献
Nishiwaki, Nagatoshi; Matsushima, Kazuo; Chatani, Miki; Tamura, Mina; Ariga, Masahiro
Synlett, 2004 , # 4 p. 703 - 707
反应条件
1: 47 percent / NaOEt / ethanol / 4 h / Heating 2: 100 percent / 80 °C View Scheme
参考文献
Synlett, , # 4 p. 703 - 707
反应条件
1: acetonitrile / 8 h / Heating 2: cc HCl, SnCl2, / 24 h / 10 °C 3: 5 h / Heating View Scheme
参考文献
Plescia; Bajardi; Raffa; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 4 p. 291 - 295
反应条件
1: acetonitrile / 8 h / Heating 2: cc HCl, SnCl2, / 24 h / 10 °C 3: 5 h / Heating View Scheme
参考文献
Plescia; Bajardi; Raffa; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 4 p. 291 - 295
反应条件
1: With sodium hydroxide; ethanol; water Heating / reflux; 2: With hydrogenchloride; water in ethanol pH=5;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/62805 A1, 2007 ;
Location in patent: Page/Page column 68 ;
WO 2007/062805 A1
反应条件
1: 85 percent / AcOH / 3 h / Heating 2: 97 percent / aq. NaOH / ethanol / 1.5 h / Heating View Scheme
参考文献
Kopp; Lancelot; Dallemagne; Rault
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1045 - 1050
反应条件
hydrazine hydrate 5 h; Heating;
参考文献
Wamhoff, Heinrich; Ertas, Muemtaz; Atta, Sanaa M. S.
Liebigs Annalen der Chemie, 1985 , # 9 p. 1910 - 1916
