5-氨基-1-甲基吡唑-4-甲酸乙酯合成路线 （共 23 条）
参考文献
Bhuiyan; Rahman, Khandker M.M.; Hossain; Rahim
Pakistan Journal of Scientific and Industrial Research, 2005 , vol. 48, # 5 p. 318 - 321
反应条件
1: With tert.-butylnitrite; copper(l) chloride in acetonitrile T=0 - 65°C; 2.5 h; 2: With hydrogenchloride in water; acetonitrile
参考文献
Anderson, Kevin William; Fotouhi, Nader; Gillespie, Paul; Goodnow, Robert Alan; Guertin, Kevin Richard; Haynes, Nancy-Ellen; Myers, Michael Paul; Pietranico-Cole, Sherrie Lynn; Qi, Lida; Rossman, Pamela Loreen; Scott, Nathan Robert; Thakkar, Kshitij Chhabilbhai; Tilley, Jefferson Wright; Zhang, Qiang
Patent: US2007/225280 A1, 2007 ;
Location in patent: Page/Page column 18 ;
US 20070225280 A1
反应条件
hydrogenchloride; sodium nitrite; copper(l) chloride 1) < 10 deg C, 10 min, 2) room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Susumu; Morimoto, Katsushi; Sato, Toshiaki
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1545 - 1547
反应条件
1: 78 percent / pyridine / 17 h / 40 °C 2: 81 percent / hydrazine hydrate / dioxane; propan-2-ol / 1.5 h / Heating 3: 75 percent / Ph3P; Et3N; Br2C2Cl4 / toluene / 18 h / 80 °C View Scheme
参考文献
Jakobsen, Palle; Horneman, Anne Marie; Persson, Egon
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 12 p. 2803 - 2812
反应条件
1: 2.) aq. KOH / 1.) 8 h, 210-215 deg C, 2.) 45 min 2: 60 percent / thionyl chloride / benzene / 4 h / Heating View Scheme
参考文献
Plescia, Salvatore; Bajardi, Maria Luisa; Daidone, Giuseppe; Roccaro, Angela
Heterocycles, 1988 , vol. 27, # 1 p. 105 - 112
反应条件
potassium hydroxide 1.) 8 h, 210-215 deg C, 2.) 45 min; Yield given. Multistep reaction;
参考文献
Plescia, Salvatore; Bajardi, Maria Luisa; Daidone, Giuseppe; Roccaro, Angela
Heterocycles, 1988 , vol. 27, # 1 p. 105 - 112
反应条件
1: 62 percent / NaH / tetrahydrofuran
2: 92 percent / H2 / Pd/C / methanol
View Scheme
参考文献
Chakrabarti, Jiban K.; Hotten, Terrence M.; Pullar, Ian A.; Tye, Nicholas C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 12 p. 2573 - 2582
反应条件
hydrogenchloride; sodium nitrite; copper(l) chloride
1) < 10 deg C, 10 min, 2) room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Susumu; Morimoto, Katsushi; Sato, Toshiaki
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1545 - 1547
反应条件
sulfuric acid; copper; acetic acid; sodium nitrite
1.) from 0 deg C to 5 deg C, 30 min, 2.) from 0 deg C to RT, 30 min; Yield given. Multistep reaction;
参考文献
Huppatz
Australian Journal of Chemistry, 1983 , vol. 36, # 1 p. 135 - 147
反应条件
tetrafluoroboric acid; sodium nitrite in water
Product distribution;
参考文献
Spassova, Maria K.; Zakharieva, Rossitza D.
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 1 p. 196 - 199
