1: With n-butyllithium in diethyl ether; hexane 1 h; Inert atmosphereReflux; 2: With iodine in diethyl ether; hexane T=0 - 20°C; Inert atmosphere;

1: 1,4-dimethoxy-2-fluorobenzene With n-butyllithium in tetrahydrofuran T=-78°C; 1.66 h; Inert atmosphereReflux; 2: 2,4,6-tri(tert-butyl)phenylmagnesium bromide in tetrahydrofuran T=-78 - 20°C; 13.5 h; Inert atmosphere; Further stages;

1: AcOH, AgNO3, aq. HNO3, Br2 2: (i) nBuLi, (ii) I2 View Scheme

N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine in N,N-dimethyl-formamide T=20°C; Inert atmosphere;

N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine; water-d2 in N,N-dimethyl-formamide T=20°C; Inert atmosphere;