反应条件
1.1: 100 percent / t-BuOK / dimethylsulfoxide / 0.03 h / 20 °C
2.1: Cp2Zr(H)Cl / tetrahydrofuran / 2.33 h / 20 - 50 °C
2.2: 65 percent / I2 / tetrahydrofuran / 0.25 h / 0 °C
3.1: pyridine; DMAP / CH2Cl2 / 3 h / 20 °C
4.1: 67.7 mg / LiN3; DMPU / 36 h / 50 - 55 °C
5.1: Cp2Zr(H)Cl / tetrahydrofuran / 0.67 h / 0 °C
5.2: ZnCl2 / tetrahydrofuran / 0.17 h / 0 °C
5.3: 80 percent / Pd(PPh3)4 / tetrahydrofuran / 0.83 h / 0 - 20 °C
6.1: Me3P / tetrahydrofuran / 4 h / 20 °C
6.2: H2O / tetrahydrofuran / 1.5 h / 20 °C
7.1: 30.4 mg / DIPEA; HATU / acetonitrile / 0.5 h / 20 °C
8.1: DBU / dimethylformamide / 60 h / 20 °C
9.1: 16.2 mg / TBAF; AcOH / tetrahydrofuran / 0.25 h / 0 °C
10.1: TsOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
View Scheme
参考文献
Thompson; Jamison; Jacobsen
Journal of the American Chemical Society, 2000 , vol. 122, # 42 p. 10482 - 10483
