8-硝基[1,2,4]三唑并[1,5-a]吡啶合成路线 （共 4 条）
反应条件
sodium hydrogencarbonate T=20°C; 1.5 h; Inert atmosphere;
参考文献
Liscio, Paride; Carotti, Andrea; Asciutti, Stefania; Karlberg, Tobias; Bellocchi, Daniele; Llacuna, Laura; Macchiarulo, Antonio; Aaronson, Stuart A; Schueler, Herwig; Pellicciari, Roberto; Camaioni, Emidio
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2807 - 2812
反应条件
1: hydrazine hydrate / methanol / 16 h / 20 °C / |Inert atmosphere 2: 2.5 h / 150 °C / |Inert atmosphere 3: sodium hydrogencarbonate / 1.5 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Liscio, Paride; Carotti, Andrea; Asciutti, Stefania; Karlberg, Tobias; Bellocchi, Daniele; Llacuna, Laura; Macchiarulo, Antonio; Aaronson, Stuart A; Schueler, Herwig; Pellicciari, Roberto; Camaioni, Emidio
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2807 - 2812
反应条件
1: 58 percent / 2.5 h / 150 °C 2: 60 percent / std. aq. NaHCO3 / 1.5 h / Ambient temperature View Scheme
参考文献
Liscio, Paride; Carotti, Andrea; Asciutti, Stefania; Karlberg, Tobias; Bellocchi, Daniele; Llacuna, Laura; Macchiarulo, Antonio; Aaronson, Stuart A; Schueler, Herwig; Pellicciari, Roberto; Camaioni, Emidio
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2807 - 2812
反应条件
hydrogen; palladium on activated charcoal in ethanol T=90°C; P=44130.5 Torr; 1.5 h;
参考文献
Bouteau, Brigitte; Lancelot, Jean-Charles; Robba, Max
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 6 p. 1649 - 1651
