(2R)-2-[(1,3-二氢-1,3-二氧代-2H-异吲哚-2-基)氧基]-4-甲基-丙酸合成路线 （共 2 条）
反应条件
1: 2-hydroxy-1,3-isoindolinedione With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 0.166667 h; Inert atmosphere; 2: S-(-)-2-bromopropionic acid in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; Inert atmosphere; 3: With hydrogenchloride in water; N,N-dimethyl-formamide; mineral oil Cooling with ice;
参考文献
Katritzky, Alan R.; Avan, Ilker; Tala, Srinivasa R.
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8690 - 8694
反应条件
trifluoroacetic acid T=0°C; 2 h;
参考文献
Wei, Jie; Shao, Xuan; Gong, Maozhen; Zhu, Beibei; Cui, Yuxin; Gao, Yanfeng; Wang, Rui
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 2986 - 2989
