(2R)-2-[(1,3-二氢-1,3-二氧代-2H-异吲哚-2-基)氧基]-4-甲基-戊酸合成路线 （共 8 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3 h;
参考文献
Yang, Dan; Qu, Jin; Li, Wei; Wang, De-Ping; Ren, Yi; Wu, Yun-Dong
Journal of the American Chemical Society, 2003 , vol. 125, # 47 p. 14452 - 14457
反应条件
hydrogen; palladium on activated charcoal in methanol Hydrogenolysis; debenzylation; P=760.051 Torr; 1 h;
参考文献
Shin; Lee; Jung; Yoon
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7667 - 7675
反应条件
1: aq. HCl; NaNO2 / 6 h / 0 °C 2: 4 h / 60 °C 3: DMAP; DCC / CH2Cl2 / 12 h / 20 °C 4: K2CO3 / methanol; H2O / 12 h / 20 °C 5: 70 percent / DEAD; PPh3 / tetrahydrofuran 6: TFA / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Shin; Lee; Jung; Yoon
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7667 - 7675
反应条件
1: 4 h / 60 °C 2: DMAP; DCC / CH2Cl2 / 12 h / 20 °C 3: K2CO3 / methanol; H2O / 12 h / 20 °C 4: 70 percent / DEAD; PPh3 / tetrahydrofuran 5: TFA / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Shin; Lee; Jung; Yoon
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7667 - 7675
反应条件
1: 99 percent / PPh3; DIAD / CH2Cl2 / 0.67 h / -40 - -20 °C 2: 79 percent / H2 / Pd/C / methanol / 1 h / 760.05 Torr View Scheme
参考文献
Shin; Lee; Jung; Yoon
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7667 - 7675
反应条件
1: DMAP; DCC / CH2Cl2 / 12 h / 20 °C 2: K2CO3 / methanol; H2O / 12 h / 20 °C 3: 70 percent / DEAD; PPh3 / tetrahydrofuran 4: TFA / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Yang; Li; Ng; Yan; Qu; Wu
Journal of Organic Chemistry, 2001 , vol. 66, # 22 p. 7303 - 7312
反应条件
1: 70 percent / DEAD; PPh3 / tetrahydrofuran 2: TFA / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Yang; Li; Ng; Yan; Qu; Wu
Journal of Organic Chemistry, 2001 , vol. 66, # 22 p. 7303 - 7312
反应条件
1: K2CO3 / methanol; H2O / 12 h / 20 °C 2: 70 percent / DEAD; PPh3 / tetrahydrofuran 3: TFA / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Yang; Li; Ng; Yan; Qu; Wu
Journal of Organic Chemistry, 2001 , vol. 66, # 22 p. 7303 - 7312
