1-氨基-3-甲基吡咯-2,4-二羧酸二甲酯合成路线 （共 5 条）
反应条件
O-(diphenyl-phosphinyl)hydroxylamine; sodium hydride in N,N-dimethyl-formamide
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
反应条件
1: AlCl3 2: NaOMe 3: Ph2P(O)ONH2; NaH / dimethylformamide View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
反应条件
1: sodium hydride / tetrahydrofuran; dimethylsulfoxide 2: AlCl3 3: NaOMe 4: Ph2P(O)ONH2; NaH / dimethylformamide View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
参考文献
Bristol Myers Squibb Company
Patent: US6982265 B1, 2006 ;
Location in patent: Page/Page column 33 ;
反应条件
1: Heating 2: POCl3 / Heating View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
