4-氯-5-甲基吡咯[2,1-F][1,2,4]三嗪-6-羧酸甲酯合成路线 （共 5 条）
反应条件
trichlorophosphate T=100°C; 15 h; Product distribution / selectivity;
参考文献
Bristol Myers Squibb Company
Patent: US6982265 B1, 2006 ;
Location in patent: Page/Page column 38; 41 ;
反应条件
1: AlCl3 2: NaOMe 3: Ph2P(O)ONH2; NaH / dimethylformamide 4: Heating 5: POCl3 / Heating View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
反应条件
1: Ph2P(O)ONH2; NaH / dimethylformamide 2: Heating 3: POCl3 / Heating View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
反应条件
1: sodium hydride / tetrahydrofuran; dimethylsulfoxide 2: AlCl3 3: NaOMe 4: Ph2P(O)ONH2; NaH / dimethylformamide 5: Heating 6: POCl3 / Heating View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
反应条件
1: Heating 2: POCl3 / Heating View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
