反应条件
1.1: K2CO4 / acetonitrile / 1 h / 70 °C
2.1: 340 mg / aq. HCl / methanol / 2 h / 80 °C
3.1: POCl3; N,N'-diisopropylethylamine / toluene / 4 h / 120 °C
4.1: NaH / dimethylformamide / -78 - 20 °C
4.2: dimethylformamide / 1 h / 20 °C
5.1: 86 percent / HCOONH4 / Pd/C / dimethylformamide / 1.5 h / 20 °C
View Scheme
参考文献
Bhide, Rajeev S.; Cai, Zhen-Wei; Zhang, Yong-Zheng; Qian, Ligang; Wei, Donna; Barbosa, Stephanie; Lombarde, Louis J.; Borzilleri, Robert M.; Zheng, Xiaoping; Wu, Laurence I.; Barrish, Joel C.; Kim, Soong-Hoon; Leavitt, Kenneth; Mathur, Arvind; Leith, Leslie; Chao, Sam; Wautlet, Barri; Mortillo, Steven; Jeyaseelan Sr., Robert; Kukral, Daniel; Hunt, John T.; Kamath, Amrita; Fura, Aberra; Vyas, Viral; Marathe, Punit; D'Arienzo, Celia; Derbin, George; Fargnoli, Joseph
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2143 - 2146