5-(乙酰氨基)-N,N'-双(2,3-二羟基丙基)-2,4,6-三碘-1,3-苯二甲酰胺合成路线 （共 20 条）
反应条件
hydrogenchloride; sodium hydroxide in 2-methoxy-ethanol T=15°C; pH=11.8 - 12.0; 40 h;
参考文献
GE Healthcare AS
Patent: EP2281802 A1, 2011 ;
Location in patent: Page/Page column 3 ;
反应条件
1: With sodium hydroxide in methanol T=45°C; 2: With hydrogenchloride in methanol; water T=15°C; 48 h; Product distribution / selectivity;
参考文献
GE HEALTHCARE AS
Patent: US2011/21829 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
potassium iodide; sodium hydroxide in isobutyramide; water 119 h; Product distribution / selectivity;
参考文献
MALLINCKRODT INC.; CAVIGGIOLA III, Tino, J.; JONES, Michelle, M.
Patent: WO2011/41276 A1, 2011 ;
Location in patent: Page/Page column 31-32 ;
反应条件
hydrogenchloride; boric acid; potassium hydroxide in water pH=10 - 11; Industry scale; Product distribution / selectivity;
参考文献
WO2011/63551 A1, ;
Page/Page column 15-16 ;
反应条件
sodium methylate in Propylene glycol
参考文献
AMERSHAM HEALTH AS
Patent: WO2005/3080 A1, 2005 ;
Location in patent: Page 2; 7 ;
反应条件
potassium hydroxide in methanol; dimethyl sulfoxide; isopropyl alcohol
参考文献
Bjorsvik, Hans-Rene; Priebe, Hanno; Cervenka, Jan; Aabye, Arne W.; Gulbrandsen, Trygve; Bryde, Arnt Christian
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 472 - 478
反应条件
sodium hydroxide; Ca(OH)2 in water
参考文献
BRACCO S.p.A.; DIBRA S.p.A.
Patent: EP915835 B1, 2000 ;
反应条件
1: With sodium hydroxide in methanol T=45°C; 2: With hydrogenchloride in methanol; water T=15°C; 48 h; Product distribution / selectivity;
参考文献
GE HEALTHCARE AS
Patent: US2011/21829 A1, 2011 ;
Location in patent: Page/Page column 5 ;
参考文献
Abbott Laboratories
Patent: US5705692 A1, 1998 ;
反应条件
in methanol; chloroform
参考文献
Nyegaard and Co. A/S
Patent: US4250113 A1, 1981 ;
