3-甲基-4-硝基苯甲酸合成路线 （共 68 条）
反应条件
pyridine; phosphorus pentachloride; trichlorophosphate in dichloromethane
参考文献
ELI LILLY AND COMPANY
Patent: EP655439 A2, 1995 ;
反应条件
phosphorus pentachloride; toluene-4-sulfonamide
参考文献
Beilstein; Kreusler
Justus Liebigs Annalen der Chemie, 1867 , vol. 144, p. 182
反应条件
phosphorus pentachloride Behandlung des entstandenen Chlorids mit konz. Ammoniak;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 144, p. 182
反应条件
thionyl chloride T=0 - 80°C; 1 h;
参考文献
US2012/277224 A1, ;
Page/Page column 33 ;
US 20120277224 A1
反应条件
in hydrogenchloride; methanol
反应条件
copper diacetate; acetic anhydride in N,N-dimethyl-formamide; acetonitrile T=130°C; 1 h; Sealed tube;
参考文献
European Journal of Organic Chemistry, , vol. 2014, # 10 p. 2027 - 2031
反应条件
sodium hydrogencarbonate in isobutyramide
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
参考文献
The DuPont Merck Pharmaceutical Company
Patent: US5760028 A1, 1998 ;
反应条件
sulfuric acid 24 h; Heating;
参考文献
Showalter, H. D. Hollis; Sun, Li; Sercel, Anthony D.; Winters, R. Thomas; Denny, William A.; Palmer, Brian D.
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 1155 - 1158
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=0°C; 18 h;
参考文献
Dhanoa, Daljit S.; Bagley, Scott W.; Chang, Raymond S. L.; Lotti, Victor J.; Chen, Tsing-Bau; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 26 p. 4239 - 4249
