5-甲基-2-硝基苯甲酸合成路线 （共 50 条）
反应条件
(electrochemical reduction);
参考文献
Le Guyader,M.
Bulletin de la Societe Chimique de France, 1966 , p. 1867 - 1872
反应条件
1: 91 percent / conc. H2SO4 / 48 h / Heating 2: 30 percent / CF3SO3H, fuming HNO3 / CH2Cl2 / 20 h / 25 °C 3: dioxane / 1.5 h / Heating 4: H2 / Pd/C / methanol / 1 h / 25 °C / 3102.9 Torr View Scheme
参考文献
Showalter, H. D. Hollis; Sun, Li; Sercel, Anthony D.; Winters, R. Thomas; Denny, William A.; Palmer, Brian D.
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 1155 - 1158
反应条件
1: tin; hydrochloric acid 2: 120 - 130 °C View Scheme
参考文献
Findeklee
Chemische Berichte, 1905 , vol. 38, p. 3555
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C;
参考文献
AVANIR PHARMACEUTICALS
Patent: WO2004/74218 A2, 2004 ;
Location in patent: Page 97 ;
参考文献
Findeklee
Chemische Berichte, 1905 , vol. 38, p. 3555
反应条件
triphenylphosphine; silver carbonate; palladium dichloride in dimethyl sulfoxide T=130°C; 6 h; Inert atmosphere;
参考文献
Xie, Kai; Wang, Sizhuo; Yang, Zhiyong; Liu, Jidan; Wang, Anwei; Li, Xiujian; Tan, Ze; Guo, Can-Cheng; Deng, Wei
European Journal of Organic Chemistry, 2011 , # 29 p. 5787 - 5790
反应条件
triphenylphosphine; silver carbonate; palladium dichloride in dimethyl sulfoxide T=130°C; 6 h; Inert atmosphere;
参考文献
Xie, Kai; Wang, Sizhuo; Yang, Zhiyong; Liu, Jidan; Wang, Anwei; Li, Xiujian; Tan, Ze; Guo, Can-Cheng; Deng, Wei
European Journal of Organic Chemistry, 2011 , # 29 p. 5787 - 5790
反应条件
triphenylphosphine; silver carbonate; palladium dichloride in dimethyl sulfoxide T=130°C; 6 h; Inert atmosphere;
参考文献
Xie, Kai; Wang, Sizhuo; Yang, Zhiyong; Liu, Jidan; Wang, Anwei; Li, Xiujian; Tan, Ze; Guo, Can-Cheng; Deng, Wei
European Journal of Organic Chemistry, 2011 , # 29 p. 5787 - 5790
反应条件
1: SOCl2; DMF / CH2Cl2 / 20 °C
2: NEt3 / CH2Cl2 / 20 °C
3: SnCl2*2H2O / ethyl acetate / Heating
View Scheme
参考文献
Chou, Yuo-Ling; Davey, David D.; Eagen, Keith A.; Griedel, Brian D.; Karanjawala, Rushad; Phillips, Gary B.; Sacchi, Karna L.; Shaw, Kenneth J.; Wu, Shung C.; Lentz, Dao; Liang, Amy M.; Trinh, Lan; Morrissey, Michael M.; Kochanny, Monica J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 507 - 511
反应条件
1: SOCl2; DMF / CH2Cl2 / 20 °C
2: NEt3 / CH2Cl2 / 20 °C
3: SnCl2*2H2O / ethyl acetate / Heating
View Scheme
参考文献
Chou, Yuo-Ling; Davey, David D.; Eagen, Keith A.; Griedel, Brian D.; Karanjawala, Rushad; Phillips, Gary B.; Sacchi, Karna L.; Shaw, Kenneth J.; Wu, Shung C.; Lentz, Dao; Liang, Amy M.; Trinh, Lan; Morrissey, Michael M.; Kochanny, Monica J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 507 - 511
