5-甲基-2-硝基苯甲酸合成路线 （共 50 条）
反应条件
1: phosphorus (V)-chloride
2: diethyl ether
3: aqueous sulfuric acid
View Scheme
参考文献
Szychowski, Janek; Mahdavi, Alborz; Hodas, Jennifer J. L.; Bagert, John D.; Ngo, John T.; Landgraf, Peter; Dieterich, Daniela C.; Schuman, Erin M.; Tirrell, David A.
Journal of the American Chemical Society, 2010 , vol. 132, # 51 p. 18351 - 18360
反应条件
1: 94 percent / dicyclohexylcarbodiimide / dimethylformamide / 1) ice bath, 10 min, 2) room temperature, 2-4 h
2: 1) H2, 2) LiAlH4 / 1) Pt / 1) methanol, 2) THF, reflux
View Scheme
参考文献
Webb, Thomas H.; Wilcox, Craig S.
Journal of Organic Chemistry, 1990 , vol. 55, # 1 p. 363 - 365
反应条件
1: 32.6 g / AcCl / Heating
2: NBS, benzoyl-peroxide / CCl4 / Heating
3: aq. NaOH, aliquat / CH2Cl2 / 5 h / Ambient temperature
View Scheme
参考文献
Bogetto, Nicole; Vilain, Anne-Cecile; Montagne, Jean-Jacques; Reboud-Ravaux, Michele; Mazaleyrat, Jean-Paul; et al.
Bulletin de la Societe Chimique de France, 1994 , vol. 131, p. 152 - 166
反应条件
tetrachlorosilane in pyridine
参考文献
Kornet, Milton J.; Tita, Terence T.; Thio, Alan P.
Synthetic Communications, 1986 , vol. 16, # 10 p. 1261 - 1274
反应条件
1: SOCl2 / 7 h / Heating
2: 78 percent / diethyl ether / Ambient temperature; overbight
View Scheme
参考文献
Kornet; Varia; Beaven
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 6 p. 1553 - 1555
反应条件
1: SOCl2 / 7 h / Heating
2: 78 percent / diethyl ether / Ambient temperature; overbight
3: 94 percent / H2 / 5percent Pd/C / ethanol / low pressure
View Scheme
参考文献
Kornet; Varia; Beaven
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 6 p. 1553 - 1555
反应条件
1: SOCl2 / 7 h / Heating
2: 78 percent / diethyl ether / Ambient temperature; overbight
3: 32 percent / 2 h / Heating
View Scheme
参考文献
Kornet; Varia; Beaven
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 6 p. 1553 - 1555
反应条件
phosphorus pentachloride
参考文献
Kornet; Varia; Beaven
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1533 - 1535
反应条件
sulfuric acid
48 h; Reflux;
参考文献
RESVERLOGIX CORP.; HANSEN, Henrik, C.; WAGNER, Gregory, S.; ATTWELL, Sarah, C.; MCLURE, Kevin, G.; KULIKOWSKI, Ewelina, B.
Patent: WO2010/123975 A1, 2010 ;
Location in patent: Page/Page column 80-82 ;
反应条件
1: With pyridine; 2,4,6-tri-fluoro-1,3,5-triazine in dichloromethane
T=-10°C; 1 h;
2: With sodium tetrahydroborate in methanol; dichloromethane
T=20°C; 0.166667 h;
3: With sulfuric acid in methanol; dichloromethane; water
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66136 A1, 2005 ;
Location in patent: Page/Page column 99-100 ;
WO 2005/066136 A1
