(2S,4R)-4-甲基谷氨酸合成路线 （共 29 条）
反应条件
1: 95 percent / TFA / CH2Cl2; H2O / 2 h / 20 °C / Acid hydrolysis 2: 98 percent / LiOH / H2O / pH 10 3: 78 percent / pyridoxal phosphate; cysteine sulfinic acid / Glutamic Oxalacetic Transaminase (GOT) / H2O / 24 h / 20 °C / pH 7 / Enzymatic reaction View Scheme
参考文献
European Journal of Organic Chemistry, , # 12 p. 3403 - 3406
反应条件
1.1: SOCl2 / 0 - 20 °C 2.1: DMAP / triethylamine; CH2Cl2 3.1: LiN(SiMe3)2 / tetrahydrofuran / -78 °C 3.2: tetrahydrofuran / -78 °C 4.1: LiOH / H2O; tetrahydrofuran 5.1: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1.1: LiN(SiMe3)2 / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran / -78 °C 2.1: LiOH / H2O; tetrahydrofuran 3.1: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1.1: LiN(SiMe3)2 / tetrahydrofuran / 0.75 h / -78 °C 1.2: 37 percent / tetrahydrofuran / -78 °C 2.1: LiOH / H2O; tetrahydrofuran 3.1: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1: LiOH / H2O; tetrahydrofuran 2: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1.1: DMAP / triethylamine; CH2Cl2 2.1: LiN(SiMe3)2 / tetrahydrofuran / -78 °C 2.2: tetrahydrofuran / -78 °C 3.1: LiOH / H2O; tetrahydrofuran 4.1: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1.1: DMAP / triethylamine; CH2Cl2 2.1: LiN(SiMe3)2 / tetrahydrofuran / 0.75 h / -78 °C 2.2: 37 percent / tetrahydrofuran / -78 °C 3.1: LiOH / H2O; tetrahydrofuran 4.1: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1: LiOH / H2O; tetrahydrofuran 2: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C 2: 6N aq. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 14 p. 2518 - 2520
