3-N-叔丁氧羰基氨基-2,6-二氧代哌啶合成路线 （共 5 条）
反应条件
4-(N,N-dimethlyamino)pyridine; 1,1'-carbonyldiimidazole in tetrahydrofuran 17 h; Heating;
参考文献
Stewart, Scott G.; Braun, Carlos J.; Ng, Sze-Ling; Polomska, Marta E.; Karimi, Mahdad; Abraham, Lawrence J.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 650 - 662
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine; 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 72 h;
参考文献
Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714
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Nakamura, Takanori; Noguchi, Tomomi; Miyachi, Hiroyuki; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 4 p. 651 - 654
反应条件
trifluoromethyl amino ketone; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine T=20°C;
参考文献
Contino-Pepin, Christiane; Parat, Audrey; Perino, Sandrine; Lenoir, Christine; Vidal, Michel; Galons, Herve; Karlik, Stephen; Pucci, Bernard
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 878 - 881
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Contino-Pepin, Christiane; Parat, Audrey; Perino, Sandrine; Lenoir, Christine; Vidal, Michel; Galons, Herve; Karlik, Stephen; Pucci, Bernard
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 878 - 881
反应条件
1: 98 percent / HBr; AcOH / 0.5 h / 20 °C
2: 98 percent / N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate; TEA / CH2Cl2 / 72 h / 20 °C
3: 59 percent / H2; acetic acid / Pd/C / ethyl acetate / 1 h / 20 °C
View Scheme
参考文献
Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1709 - 1714
