2-溴-5-苯甲酰基噻吩合成路线 （共 13 条）
反应条件
aluminium trichloride in carbon disulfide Friedel-Crafts acylation; 2.5 h;
参考文献
NORTHWESTERN UNIVERSITY
Patent: WO2007/50049 A1, 2007 ;
Location in patent: Page/Page column 27-29 ;
反应条件
sodium carbonate; palladium dichloride in water; acetone T=20°C; 1 h;
参考文献
Korolev; Bumagin
Russian Chemical Bulletin, 2004 , vol. 53, # 2 p. 364 - 369
参考文献
Journal of the American Chemical Society, , vol. 59, p. 2699,2700
反应条件
1: (4-fluoro-phenyl)-magnesium bromide With bismuth(III) chloride 2: 2-benzoyl-5-bromothiophene With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Synlett, , # 9 p. 1324 - 1330
反应条件
1: thien-2-ylmagnesium bromide With bismuth(III) chloride 2: 2-benzoyl-5-bromothiophene With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
1: NaBH4 / ethanol / 1.) RT, 15 min, 2.) heating 2: 53 percent / dry HCl / 24 h / Ambient temperature 3: 84 percent / dimethylsulfoxide / 24 h / Ambient temperature 4: 80 percent / 4M aq. HCl / 1 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 275 - 282
反应条件
1: (4-Methylphenyl)-magnesium bromide With bismuth(III) chloride 2: 2-benzoyl-5-bromothiophene With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
1: 4-methoxyphenyl magnesium bromide With bismuth(III) chloride 2: 2-benzoyl-5-bromothiophene With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
potassium dihydrogenphosphate; palladium diacetate in ethanol; water
T=77 - 80°C; Suzuki-Miyaura cross-coupling; 2 h;
参考文献
Guo, Sheng-Rong; Yuan, Yan-Qin
Journal of Chemical Research, 2009 , # 12 p. 745 - 749
反应条件
1: phenyl-magnesium bromide With bismuth(III) chloride
2: 2-benzoyl-5-bromothiophene With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide
T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
